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{{Infobox enzyme
| Name = Exo-(1->4)-alpha-D-glucan lyase
| EC_number = 4.2.2.13
| CAS_number = 148710-18-3
| IUBMB_EC_number = 4/2/2/13
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Exo-(1->4)-alpha-D-glucan lyase''' ({{EC number|4.2.2.13}}, ''alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase'', ''alpha-1,4-glucan exo-lyase'', ''alpha-1,4-glucan lyase'', ''GLase'') is an [[enzyme]] with system name ''(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)''.<ref>{{cite journal | title = &alpha;-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. I. Efficient purification and characterization from red seaweeds |author = Yu, S., Kenne, L., Peders&eacute;n, M. |journal = Biochim. Biophys. Acta |year = 1993 |volume = 1156 |pages = 313–320 |pmid = 8461323}}</ref><ref>{{cite journal | title = &alpha;-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. II. Subcellular localization and partial amino-acid sequence |author = Yu, S., Peders&eacute;n, M. |journal = Planta |year = 1993 |volume = 191 |pages = 137–142 |pmid = 7763826}}</ref><ref>{{cite journal | title = &alpha;-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. III. Substrate specificity, mode of action, and cleavage mechanism |author = Yu, S., Ahmad, T., Kenne, L. and Peders&eacute;n, M. |journal = Biochim. Biophys. Acta |year = 1995 |volume = 1244 |pages = 1–9 |pmid = 7766642}}</ref><ref>{{cite journal | title = Efficient purification, characterization and partial amino acid sequencing of two &alpha;-1,4-glucan lyases from fungi |author = Yu, S., Christensen, T.M., Kragh, K.M., Bojsen, K. and Marcussen, J. |journal = Biochim. Biophys. Acta |year = 1997 |volume = 1339 |pages = 311–320 |pmid = 9187252}}</ref><ref>{{cite journal | title = &alpha;-1,4-glucan lyases producing 1,5-anhydro-D-fructose from starch and glycogen have sequence similarity to &alpha;-glucosidases |author = Yu, S., Bojsen, K., Svensson, B. and Marcussen, J. |journal = Biochim. Biophys. Acta |year = 1999 |volume = 1433 |pages = 1–15 |pmid = 10446355}}</ref><ref>{{cite journal | title = &alpha;-1,4-Glucan lyase performs a ''trans''-elimination via a nucleophilic displacement followed by a syn-elimination |author = Lee, S.S., Yu, S. and Withers, S.G. |journal = J. Am. Chem. Soc. |year = 2002 |volume = 124 |pages = 4948–4949 |pmid = 11982345}}</ref><ref>{{cite journal | title = Detailed dissection of a new mechanism for glycoside cleavage: &alpha;-1,4-glucan lyase |author = Lee, S.S., Yu, S. and Withers, S.G. |journal = Biochemistry |year = 2003 |volume = 42 |pages = 13081–13090 |pmid = 14596624}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: linear alpha-glucan <math>\rightleftharpoons</math> (n-1) 1,5-anhydro-D-fructose + D-[[glucose]]

The enzyme catalyses the sequential degradation of (1->4)-alpha-D-glucans from the non-reducing end.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Exo-(1->4)-alpha-D-glucan+lyase}}

[[Category:EC 4.2.2]]