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{{enzyme
| Name = D-dopachrome decarboxylase
| EC_number = 4.1.1.84
| CAS_number = 184111-06-6
| IUBMB_EC_number = 4/1/1/84
| GO_code =
| image =
| width =
| caption =
}}
In [[enzymology]], a '''D-dopachrome decarboxylase''' ({{EC number|4.1.1.84}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:D-dopachrome <math>\rightleftharpoons</math> 5,6-dihydroxyindole + CO<sub>2</sub>

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[D-dopachrome]], and two [[product (chemistry)|products]], [[5,6-dihydroxyindole]] and [[carbon dioxide|CO<sub>2</sub>]].

This enzyme belongs to the family of [[lyase]]s, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is '''D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming)'''. Other names in common use include '''phenylpyruvate tautomerase II''', '''D-tautomerase''', '''D-dopachrome tautomerase''', and '''D-dopachrome carboxy-lyase'''.

==References==
{{reflist|1}}
* {{cite journal | author = Odh G, Hindemith A, Rosengren AM, Rosengren E, Rorsman H | date = 1993 | title = Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole | journal = Biochem. Biophys. Res. Commun. | volume = 197 | pages = 619–24 | pmid = 8267597 | doi = 10.1006/bbrc.1993.2524 | issue = 2 }}
* {{cite journal | author = Yoshida H, Nishihira J, Suzuki M, Hikichi K | date = 1997 | title = NMR characterization of physicochemical properties of rat D-dopachrome tautomerase | journal = Biochem. Mol. Biol. Int. | volume = 42 | pages = 891–9 | pmid = 9285056 | issue = 5 }}
* {{cite journal | author = J | date = 1999 | title = Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution | journal = Biochemistry. | volume = 38 | pages = 3268–79 | pmid = 10079069 | doi = 10.1021/bi982184o | last2 = Taniguchi | first2 = M | last3 = Nakagawa | first3 = A | last4 = Tanaka | first4 = I | last5 = Suzuki | first5 = M | last6 = Nishihira | first6 = J | issue = 11 }}
* {{cite journal | author = A, Tanaka I, Sakai M | date = 1998 | title = Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation | journal = Biochem. Biophys. Res. Commun. | volume = 243 | pages = 538–44 | pmid = 9480844 | doi = 10.1006/bbrc.1998.8123 | issue = 2 }}

{{4.1-enzyme-stub}}

[[Category:EC 4.1.1]]
[[Category:Enzymes of unknown structure]]

Benzylsuccinate synthase - Revision history

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