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| {{enzyme
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| | Name = 15-oxoprostaglandin 13-oxidase
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| | EC_number = 1.3.1.48
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| | CAS_number = 57406-74-3
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| | IUBMB_EC_number = 1/3/1/48
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| | GO_code = 0047522
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| }}
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| In [[enzymology]], a '''15-oxoprostaglandin 13-oxidase''' ({{EC number|1.3.1.48}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ <math>\rightleftharpoons</math> (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H<sup>+</sup>
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is '''(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase'''. Other names in common use include '''15-oxo-Delta13-prostaglandin reductase''', '''Delta13-15-ketoprostaglandin reductase''', '''15-ketoprostaglandin Delta13-reductase''', '''prostaglandin Delta13-reductase''', '''prostaglandin 13-reductase''', and '''15-ketoprostaglandin Delta13-reductase'''.
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| ==Structural studies==
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| As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1V3T}}, {{PDB link|1V3U}}, {{PDB link|1V3V}}, and {{PDB link|2DM6}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Hansen HS | date = 1982 | title = Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lung | journal = Methods Enzymol. | volume = 86 | pages = 156–63 | pmid = 6290839 | doi = 10.1016/0076-6879(82)86186-7 }}
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| * {{cite journal | author = Jarabak J | date = 1982 | title = Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placenta | journal = Methods Enzymol. | volume = 86 | pages = 163–7 | pmid = 7132753 | doi = 10.1016/0076-6879(82)86187-9 }}
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| {{1.3-enzyme-stub}}
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| [[Category:EC 1.3.1]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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Jayson Berryhill is how I'm called and my wife doesn't like it at all. Mississippi is exactly where his home is. The preferred hobby for him and his kids is to perform lacross and he would never give it up. Distributing production is exactly where my primary earnings comes from and it's something I really appreciate.
My web site psychic love readings (www.skullrocker.com)