Retardation factor: Difference between revisions
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The '''Certain Safety Factor''' is the ratio of the [[lethal dose]] to 1% of population to the [[Effective dose (pharmacology)|effective dose]] to 99% of the population (LD1/ED99). This is a better safety index than the [[Median lethal dose|LD<sub>50</sub>]] for materials that have both desirable and undesirable effects, because it factors in the ends of the spectrum where doses may be necessary to produce a response in one person but can, at the same dose, be lethal in another. | |||
<math>\mbox{Certain safety factor} = \frac{\mathrm{LD}_{1}}{\mathrm{ED}_{99}}</math> | |||
==See also== | |||
* [[Therapeutic index]] | |||
* [[Effective dose (pharmacology)|Effective dose]] | |||
* [[IC50|IC<sub>50</sub>]] | |||
* {{LD50}} | |||
* [[EC50|EC<sub>50</sub>]] | |||
* [[Toxicology]] | |||
==References== | |||
http://www.courses.vcu.edu/ptxed/m2/faqs_damaj.htm | |||
[[Category:Pharmacology]] | |||
[[Category:Toxicology]] | |||
{{pharma-stub}} | |||
{{med-toxic-stub}} | |||
Revision as of 22:28, 16 January 2014
The Certain Safety Factor is the ratio of the lethal dose to 1% of population to the effective dose to 99% of the population (LD1/ED99). This is a better safety index than the LD50 for materials that have both desirable and undesirable effects, because it factors in the ends of the spectrum where doses may be necessary to produce a response in one person but can, at the same dose, be lethal in another.
See also
References
http://www.courses.vcu.edu/ptxed/m2/faqs_damaj.htm
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