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[[File:Quaternary ammonium cation.svg|thumb|right|Quaternary ammonium cation. The R groups may be the same or different alkyl or aryl groups. Also, the R groups may be connected.]]
 
'''[[Quaternary compound|Quaternary]] ammonium cations''', also known as '''quats''', are positively charged [[polyatomic ion]]s of the structure NR<sub>4</sub><sup>+</sup>, R being an [[alkyl]] group or an [[aryl]] group.<ref>{{GoldBookRef | file = Q05003 | title = quaternary ammonium compounds }}</ref> Unlike the [[ammonium|ammonium ion]] (NH<sub>4</sub><sup>+</sup>) and the primary, secondary, or tertiary ammonium [[cations]], the quaternary ammonium cations are permanently charged, independent of the [[pH]] of their solution. '''Quaternary ammonium salts''' or '''quaternary ammonium compounds''' (called '''quaternary amines''' in oilfield parlance) are [[salt (chemistry)|salt]]s of quaternary ammonium cations with an [[anion]].
 
== Synthesis ==
Quaternary ammonium compounds are prepared by [[alkylation]] of tertiary amines, in a process called '''quaternization'''.<ref>{{March5th}}</ref> Typically one of the alkyl groups on the amine is larger than the others.<ref>Kosswig, K. “Surfactants” in Ullmann’s Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. {{DOI|10.1002/14356007.a25_747}}.</ref> A typical synthesis is for [[benzalkonium chloride]] from a long-chain alkyldimethylamine and [[benzyl chloride]]:
:CH<sub>3</sub>(CH<sub>2</sub>)<sub>n</sub>N(CH<sub>3</sub>)<sub>2</sub>  +  ClCH<sub>2</sub>C<sub>6</sub>H<sub>5</sub>  →  [CH<sub>3</sub>(CH<sub>2</sub>)<sub>n</sub>N(CH<sub>3</sub>)<sub>2</sub>CH<sub>2</sub>C<sub>6</sub>H<sub>5</sub>]<sup>+</sup>Cl<sup>-</sup>
 
==Reactions==
While not very reactive, quaternary ammonium salts undergo [[Sommelet–Hauser rearrangement]]<ref>{{OrgSynth | collvol = 4 | collvolpages = 585 | year = 1963 | title = 2-Methylbenzyldimethylamine | author1 = W. R. Brasen | author2 = C. R. Hauser}}</ref> and [[Stevens rearrangement]],<ref>{{cite journal | doi = 10.1002/0471264180.or018.04 | chapter = The Base-Promoted Rearrangements of Quaternary Ammonium Salts | title = Organic Reactions | year = 2011 | last1 = Pine | first1 = Stanley H. | isbn = 0471264180}}</ref> as well as dealkylation under harsh conditions. Quaternary ammonium cations can also undergo the [[Hofmann Elimination]] and [[Emde degradation]] if there are hydrogens beta to the nitrogen.
 
==Applications==
Quaternary ammonium salts are used as [[disinfectant]]s, [[surfactants]], [[fabric softener]]s, and as [[antistatic agent]]s (e.g. in [[shampoo]]s). In [[liquid]] fabric softeners, the [[chloride]] salts are often used. In [[clothes dryer|dryer]] [[fabric softener|anticling]] strips, the [[sulfate]] salts are often used. Spermicidal jellies also contain quaternary ammonium salts.
 
===As antimicrobials===
Quaternary ammonium compounds have also been shown to have antimicrobial activity.<ref>{{cite journal | doi = 10.1016/S0008-6215(01)00112-4 | title = Synthesis and antibacterial activities of quaternary ammonium salt of chitosan | year = 2001 | last1 = Jia | first1 = Zhishen | last2 = Shen | first2 = Dongfeng | last3 = Xu | first3 = Weiliang | journal = Carbohydrate Research | volume = 333 | pages = 1–6 | pmid = 11423105 |issue=1}}</ref> Certain quaternary ammonium compounds, especially those containing long alkyl chains, are used as [[antimicrobial]]s and [[disinfectant]]s. Examples are [[benzalkonium chloride]], [[benzethonium chloride]], methylbenzethonium chloride, cetalkonium chloride, [[cetylpyridinium chloride]], [[cetrimonium]], [[cetrimide]], dofanium chloride, [[tetraethylammonium bromide]], [[didecyldimethylammonium chloride]] and domiphen bromide. Also good against fungi, amoeba, and enveloped viruses,<ref name=questionable>[http://www.mansfield.ohio-state.edu/~sabedon/biol2032.htm ''Specific Antimicrobials''], outline of lecture by Stephen T. Abedon, Ohio State U., URL accessed Dec 2008.</ref> quats act by disrupting the cell membrane.{{citation needed|date=January 2013}} Quaternary ammonium compounds are lethal to a wide variety of organisms except [[endospores]], ''[[Mycobacterium tuberculosis]]'' and [[non-enveloped virus]]es.
 
In contrast to phenolics, quaternary ammonium compounds are not very effective in the presence of organic compounds. Yet, they are very effective in combination with phenols. Quaternary ammonium compounds are deactivated by soaps, other anionic detergents, and cotton fibers.<ref name=questionable/> Also, they are not recommended for use in hard water. Effective levels are at 200 ppm.<ref>[http://mark.asci.ncsu.edu/HealthyHogs/book1993/ladd1.htm ''The Use of Disinfectants In the Swine Industry''], Mark G. Ladd, North Carolina State Univ., URL accessed Dec 2008.</ref> They are effective at temperatures up to {{convert|212|F|C|abbr=on}}.
 
Quaternary ammonium salts are popular chemicals used in [[foodservice]] industry as sanitizing agents.
 
===As phase transfer catalysts===
In organic synthesis, quaternary ammonium salts are employed as [[phase transfer catalyst]]s ('''PTC'''). Such catalysts accelerate reactions between reagents dissolved in immiscible solvents. The highly reactive reagent [[dichlorocarbene]] is generated via PTC by reaction of chloroform and sodium hydroxide.
 
===Osmolytes===
Quaternary ammonium compounds are present in [[osmolyte]]s, specifically [[glycine betaine]], which stabilize osmotic pressure in cells.<ref>http://dx.doi.org/10.1128/AEM.67.6.2692-2698.2001 Sleator, Roy D., Wouters, Jeroen, Gahan, Cormac G. M., Abee, Tjakko, Hill, Colin
Analysis of the Role of OpuC, an Osmolyte Transport System, in Salt Tolerance and Virulence Potential of Listeria monocytogenes
Appl. Environ. Microbiol. 2001 67: 2692-2698</ref>
 
===Plant growth retardants===
Cycocel (chlormequat chloride) reduces plant height by inhibiting the production of gibberellins, the primary plant hormones responsible for cell elongation. Therefore, their effects are primarily on stem, petiole and flower stalk tissues. Lesser effects are seen in reductions of leaf expansion, resulting in thicker leaves with darker green color.<ref>http://users.in.gr/dimpet/thesis/growth_retardants.htm Wageningen Agricultural University, The Netherlands</ref>
 
== Health effects ==
Quaternary ammonium compounds can display a range of health effects, amongst which are mild skin and respiratory irritation <ref>{{cite journal | doi = 10.1186/1476-069X-8-11 | title = Characterization of occupational exposures to cleaning products used for common cleaning tasks-a pilot study of hospital cleaners | year = 2009 | last1 = Bello | first1 = Anila | last2 = Quinn | first2 = Margaret M | last3 = Perry | first3 = Melissa J | last4 = Milton | first4 = Donald K | journal = Environmental Health | volume = 8 | pages = 11 | pmid = 19327131 | pmc = 2678109}}</ref> up to severe caustic burns on skin and gastro-intestinal lining (depending on concentration), gastro-intestinal symptoms (e.g., nausea and vomiting), coma, convulsions, hypotension and death.<ref>[http://www.inchem.org/documents/pims/chemical/pimg022.htm#SectionTitle:2.1%20%20Main%20risk%20and%20target%20organs Quaternary ammonium (PIM G022)]</ref>
 
They are thought to be the chemical group responsible for [[anaphylactic reaction]]s that occur with use of [[neuromuscular blocking drug]]s during [[general anaesthesia]] in [[surgery]].<ref>{{cite journal | pmid = 19143700 | year = 2009 | last1 = Harper | first1 = NJ | last2 = Dixon | first2 = T | last3 = Dugué | first3 = P | last4 = Edgar | first4 = DM | last5 = Fay | first5 = A | last6 = Gooi | first6 = HC | last7 = Herriot | first7 = R | last8 = Hopkins | first8 = P | last9 = Hunter | first9 = JM | last10 = Mirakian | first10 = R | last11 = Pumphrey | first11 = RS | last12 = Seneviratne | first12 = SL | last13 = Walls | first13 = AF | last14 = Williams | first14 = P | last15 = Wildsmith | first15 = JA | last16 = Wood | first16 = P | last17 = Nasser | first17 = AS | last18 = Powell | first18 = RK | last19 = Mirakhur | first19 = R | last20 = Soar | first20 = J | author21 = Working Party of the Association of Anaesthetists of Great Britain Ireland | title = Suspected anaphylactic reactions associated with anaesthesia | volume = 64 | issue = 2 | pages = 199–211 | doi = 10.1111/j.1365-2044.2008.05733.x | pmc = 3082210 | journal = Anaesthesia}}</ref> [[Quaternium-15]] is the single most often found cause of allergic [[contact dermatitis]] of the hands (16.5% in 959 cases)<ref>{{cite journal | pmid = 17553593 | year = 2007 | last1 = Warshaw | first1 = EM | last2 = Ahmed | first2 = RL | last3 = Belsito | first3 = DV | last4 = Deleo | first4 = VA | last5 = Fowler Jr | first5 = JF | last6 = Maibach | first6 = HI | last7 = Marks Jr | first7 = JG | last8 = Toby Mathias | first8 = CG | last9 = Pratt | first9 = MD | last10 = Rietschel | first10 = RL | last11 = Sasseville | first11 = D | last12 = Storrs | first12 = FJ | last13 = Taylor | first13 = JS | last14 = Zug | first14 = KA | author15 = North American Contact Dermatitis Group | title = Contact dermatitis of the hands: Cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004 | volume = 57 | issue = 2 | pages = 301–14 | doi = 10.1016/j.jaad.2007.04.016 | journal = Journal of the American Academy of Dermatology}}</ref>
 
===Reproductive effects of trace amounts===
Quaternary ammonium-based disinfectants (Virex and Quatricide) were tentatively identified ''(by researcher Patricia Hunt - who previously uncovered the reproductive system effects of [[bisphenol A]])'' and were also identified by researchers at other labs, as the most probable cause of jumps in birth defects and fertility problems in caged lab mice.<ref name="mice">{{cite journal | doi = 10.1038/453964a |date=June 2008 | author = Hunt, P | title = Lab disinfectant harms mouse fertility. Patricia Hunt interviewed by Brendan Maher | volume = 453 | issue = 7198 | pages = 964 | pmid = 18563110 | journal = Nature }}</ref>
 
===Quantification===
As [[quaternary ammonium compounds]] are classified as large volume chemicals (extensively used as antimicrobial agents, [[herbicides]] and detergents), they are one of the major environmental contaminants. Therefore, it is of interest to know about their impact on ecosystem. However, their quantification from environmental and biological samples is a major problem using conventional chromatography techniques as they are highly soluble in water. Interestingly, while analyzing them by [[liquid chromatography–mass spectrometry|liquid chromatography coupled tandem mass spectrometry]] it has been found that they follow an exception rule. Under standard [[electrospray ionization]] (ESI) conditions mono- and di-quaternary ammonium compounds form molecular ions with the formula of <math>m^q / z^q</math> rather than <math>( m + z )/ z</math>. Formation of <math>m^q / 2</math> is observed for di-quaternary ammonium compounds (like [[diquat]]) as precursor ion and <math>m^q / 1</math> as product ion due to the loss of one of the quaternary charge during CID. In di-quaternary ammonium compounds, this process can also result in the formation of fragment ions with higher mass as compared to their precursor ion. [[Hydrophilic interaction liquid chromatography|Hydrophilic interaction liquid chromatographic]] separation has been reported to demonstrate a successful separation of quaternary ammonium compounds for their quantification in ESI-MS/MS with higher precision.<ref>{{cite journal |doi =10.1080/00032719.2012.693140 |date= October 2012 |author1=Thirumurthy Velpandiana |author2=Jayabalan Nirmala |author3=Beauty Aroraa |author4=Alok Kumar Ravia |author5=Ankita Kotnalaa |title=Understanding the Charge Issues in Mono and di-Quaternary Ammonium Compounds for Their Determination by LC/ESI-MS/MS |volume=45 |issue=16 |pages=2367–2376 |journal=Analytical Letters}}</ref>
 
== See also ==
* [[Benzalkonium chloride]], [[benzethonium chloride]], methylbenzethonium chloride, cetalkonium chloride, [[cetylpyridinium chloride]], [[cetrimonium]], [[cetrimide]], dofanium chloride, [[tetraethylammonium bromide]], and domiphen bromide – [[antimicrobial]] ingredients found in various over-the-counter products
* [[Diquat]] -diquaternary ammonium compound recognized as a contact herbicide
* [[Carnitine]]
* [[Cetyl trimethylammonium bromide]] (CTAB), [[stearalkonium chloride]] – [[cationic]] [[surfactant]]s commonly used in toiletries
* [[Choline]]
* [[Cocamidopropyl betaine]] (CAPB), a common [[Zwitterion]]ic [[surfactant]] used ubiquitously in toiletries
* [[Denatonium]], the most bitter compound known
* [[Dimethyldioctadecylammonium chloride]]
* [[Paraquat]], an herbicide
* [[Polyquaternium]], designations for quaternary ammonium-containing polymers used for personal care products
* [[Quaternary ammonium muscle relaxants]]
* [[Tetra-n-butylammonium bromide]] and [[Aliquat 336]], common [[phase transfer catalyst]]s
* [[Tetramethylammonium chloride]]
* [[Tetramethylammonium hydroxide]]
* [[Tetramethylammonium pentafluoroxenate]], containing the unusual pentagonal pentafluoroxenate (XeF<sub>5</sub><sup>-</sup>) ion
* [[Triazene cleavage]]
 
== References ==
{{reflist}}
 
==External links==
* [http://www.inchem.org/documents/pims/chemical/pimg022.htm Toxicities of quaternary ammonium]
 
[[Category:Quaternary ammonium compounds| ]]
[[Category:Disinfectants]]
[[Category:Food safety]]

Revision as of 09:01, 3 February 2014

Quaternary ammonium cation. The R groups may be the same or different alkyl or aryl groups. Also, the R groups may be connected.

Quaternary ammonium cations, also known as quats, are positively charged polyatomic ions of the structure NR4+, R being an alkyl group or an aryl group.[1] Unlike the ammonium ion (NH4+) and the primary, secondary, or tertiary ammonium cations, the quaternary ammonium cations are permanently charged, independent of the pH of their solution. Quaternary ammonium salts or quaternary ammonium compounds (called quaternary amines in oilfield parlance) are salts of quaternary ammonium cations with an anion.

Synthesis

Quaternary ammonium compounds are prepared by alkylation of tertiary amines, in a process called quaternization.[2] Typically one of the alkyl groups on the amine is larger than the others.[3] A typical synthesis is for benzalkonium chloride from a long-chain alkyldimethylamine and benzyl chloride:

CH3(CH2)nN(CH3)2 + ClCH2C6H5 → [CH3(CH2)nN(CH3)2CH2C6H5]+Cl-

Reactions

While not very reactive, quaternary ammonium salts undergo Sommelet–Hauser rearrangement[4] and Stevens rearrangement,[5] as well as dealkylation under harsh conditions. Quaternary ammonium cations can also undergo the Hofmann Elimination and Emde degradation if there are hydrogens beta to the nitrogen.

Applications

Quaternary ammonium salts are used as disinfectants, surfactants, fabric softeners, and as antistatic agents (e.g. in shampoos). In liquid fabric softeners, the chloride salts are often used. In dryer anticling strips, the sulfate salts are often used. Spermicidal jellies also contain quaternary ammonium salts.

As antimicrobials

Quaternary ammonium compounds have also been shown to have antimicrobial activity.[6] Certain quaternary ammonium compounds, especially those containing long alkyl chains, are used as antimicrobials and disinfectants. Examples are benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetalkonium chloride, cetylpyridinium chloride, cetrimonium, cetrimide, dofanium chloride, tetraethylammonium bromide, didecyldimethylammonium chloride and domiphen bromide. Also good against fungi, amoeba, and enveloped viruses,[7] quats act by disrupting the cell membrane.Potter or Ceramic Artist Truman Bedell from Rexton, has interests which include ceramics, best property developers in singapore developers in singapore and scrabble. Was especially enthused after visiting Alejandro de Humboldt National Park. Quaternary ammonium compounds are lethal to a wide variety of organisms except endospores, Mycobacterium tuberculosis and non-enveloped viruses.

In contrast to phenolics, quaternary ammonium compounds are not very effective in the presence of organic compounds. Yet, they are very effective in combination with phenols. Quaternary ammonium compounds are deactivated by soaps, other anionic detergents, and cotton fibers.[7] Also, they are not recommended for use in hard water. Effective levels are at 200 ppm.[8] They are effective at temperatures up to Template:Convert.

Quaternary ammonium salts are popular chemicals used in foodservice industry as sanitizing agents.

As phase transfer catalysts

In organic synthesis, quaternary ammonium salts are employed as phase transfer catalysts (PTC). Such catalysts accelerate reactions between reagents dissolved in immiscible solvents. The highly reactive reagent dichlorocarbene is generated via PTC by reaction of chloroform and sodium hydroxide.

Osmolytes

Quaternary ammonium compounds are present in osmolytes, specifically glycine betaine, which stabilize osmotic pressure in cells.[9]

Plant growth retardants

Cycocel (chlormequat chloride) reduces plant height by inhibiting the production of gibberellins, the primary plant hormones responsible for cell elongation. Therefore, their effects are primarily on stem, petiole and flower stalk tissues. Lesser effects are seen in reductions of leaf expansion, resulting in thicker leaves with darker green color.[10]

Health effects

Quaternary ammonium compounds can display a range of health effects, amongst which are mild skin and respiratory irritation [11] up to severe caustic burns on skin and gastro-intestinal lining (depending on concentration), gastro-intestinal symptoms (e.g., nausea and vomiting), coma, convulsions, hypotension and death.[12]

They are thought to be the chemical group responsible for anaphylactic reactions that occur with use of neuromuscular blocking drugs during general anaesthesia in surgery.[13] Quaternium-15 is the single most often found cause of allergic contact dermatitis of the hands (16.5% in 959 cases)[14]

Reproductive effects of trace amounts

Quaternary ammonium-based disinfectants (Virex and Quatricide) were tentatively identified (by researcher Patricia Hunt - who previously uncovered the reproductive system effects of bisphenol A) and were also identified by researchers at other labs, as the most probable cause of jumps in birth defects and fertility problems in caged lab mice.[15]

Quantification

As quaternary ammonium compounds are classified as large volume chemicals (extensively used as antimicrobial agents, herbicides and detergents), they are one of the major environmental contaminants. Therefore, it is of interest to know about their impact on ecosystem. However, their quantification from environmental and biological samples is a major problem using conventional chromatography techniques as they are highly soluble in water. Interestingly, while analyzing them by liquid chromatography coupled tandem mass spectrometry it has been found that they follow an exception rule. Under standard electrospray ionization (ESI) conditions mono- and di-quaternary ammonium compounds form molecular ions with the formula of rather than . Formation of is observed for di-quaternary ammonium compounds (like diquat) as precursor ion and as product ion due to the loss of one of the quaternary charge during CID. In di-quaternary ammonium compounds, this process can also result in the formation of fragment ions with higher mass as compared to their precursor ion. Hydrophilic interaction liquid chromatographic separation has been reported to demonstrate a successful separation of quaternary ammonium compounds for their quantification in ESI-MS/MS with higher precision.[16]

See also

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

External links

  1. Template:GoldBookRef
  2. Template:March5th
  3. Kosswig, K. “Surfactants” in Ullmann’s Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. Electronic Instrument Positions Staff (Standard ) Cameron from Clarence Creek, usually spends time with hobbies and interests which include knotting, property developers in singapore apartment For sale and boomerangs. Has enrolled in a world contiki journey. Is extremely thrilled specifically about visiting ..
  4. Template:OrgSynth
  5. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang
  6. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang
  7. 7.0 7.1 Specific Antimicrobials, outline of lecture by Stephen T. Abedon, Ohio State U., URL accessed Dec 2008.
  8. The Use of Disinfectants In the Swine Industry, Mark G. Ladd, North Carolina State Univ., URL accessed Dec 2008.
  9. http://dx.doi.org/10.1128/AEM.67.6.2692-2698.2001 Sleator, Roy D., Wouters, Jeroen, Gahan, Cormac G. M., Abee, Tjakko, Hill, Colin Analysis of the Role of OpuC, an Osmolyte Transport System, in Salt Tolerance and Virulence Potential of Listeria monocytogenes Appl. Environ. Microbiol. 2001 67: 2692-2698
  10. http://users.in.gr/dimpet/thesis/growth_retardants.htm Wageningen Agricultural University, The Netherlands
  11. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang
  12. Quaternary ammonium (PIM G022)
  13. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang
  14. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang
  15. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang
  16. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang