List of taxa named by Ruiz and Pavón

{{chembox | Watchedfields = changed | verifiedrevid = 399191626 |ImageFile=10-formyl-tetrahydrofolic acid.svg |ImageSize= |IUPACName=(2S)-2-{[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)
methyl(formyl)amino]benzoyl]amino}pentanedioic acid |OtherNames= 10-CHO-THF |Section1= Template:Chembox Identifiers |Section2= Template:Chembox Properties |Section3= Template:Chembox Hazards }}

10-Formyltetrahydrofolate (10-CHO-THF) is form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-CHO-THF is used as a substrate in formyltransferase reactions. This is important in purine biosynthesis, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase, as well as in the formylation of the methionyl initiator tRNA (fMet-tRNA), when 10-CHO-THF is a substrate for methionyl-tRNA formyltransferase.

Biosynthesis

10-CHO-THF is produced either by the enzyme methenyltetrahydrofolate cyclohydrolase via the reaction

5,10-methenyltetrahydrofolate + H₂O $\rightleftharpoons$ 10-formyltetrahydrofolate

and by the enzyme formate-tetrahydrofolate ligase via the reaction

ATP + formate + tetrahydrofolate $\rightleftharpoons$ ADP + phosphate + 10-formyltetrahydrofolate

It can be converted back into tetrahydrofolate (THF) by formyltetrahydrofolate dehydrogenase or THF and formate by formyltetrahydrofolate deformylase.

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